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Viagra is getting a cheaper, generic makeover from Pfizer in an effort to preempt competitors.Pfizer has repackaged its famous little blue impotence pill in a white tablet, called sildenafil, and will slash the$65-a-pill retail price of its blockbuster drug by half starting Monday.The pharmaceutical giant's patent for Viagra is set to expire next week, opening the flood gates for competitors to jump into the market with their cheaper generic versions.Rather than lose most of its sales to other companies, Pfizer is banking on the lower price point of and the 40 percent of its customer base that claims to be loyal to Viagra to help the company ride the wave of generics slated to undercut Viagra's prices by as much as 90 percent.'Patients are paying fortunes. When generic Viagra comes out, they will be very happy,' said Dr Nachum Katlowitz, a urologist at New York's Staten Island University Hospital.Launched in 1998, Viagra was the first pill for impotence. It transformed a private frustration for many aging men into a publicly discussed medical condition with an easy treatment, far more appealing than options like penile injections and implants. Pfizer's early TV ads for the little blue pill even coined the term erectile dysfunction, ED for short.Eli Lilly's Cialis came out in 2003 and now dominates the U.S. market with on-demand pills and daily, low-dose ones. Viagra is a close second.Pfizer says its market research shows 20 percent of customers are loyal to Viagra. So rather than give up sales to generic makers as brand-name drug makers once routinely did, the company is selling its own generic and also fighting to keep men on its blue pills.'We believe that the story for Viagra isn't done. It's just going to be a new chapter,' said Jim Sage, president of U.S. brands for Pfizer Essential Health, which sells its older medicines.In January, the drug maker will offer two new discount programs and increase its co-payment card discounts. Uninsured men can get brand-name Viagra half off through an innovative online home delivery program, Pfizer Direct. Many insured patients will be able to get a month's prescription - typically six to 10 pills, depending on plan limits - for as little as a $20 co-payment.'This is the most comprehensive pricing and marketing response I've seen to a generic,' said Erik Gordon, a pharmaceuticals analyst at the University of Michigan's business school. 'It's unprecedented.'Gordon thinks Pfizer's reduced prices will retain some patients and attract others who buy pills, often counterfeits, from the internet.Dr. Matthias Hofer, a urologist at Northwestern Memorial Hospital in Chicago, said some of his insured patients who take Viagra wouldn't want a generic. 'They will be ecstatic if they can save money and get the brand product from Pfizer,' he said.Last year, more than 12 million prescriptions for Viagra and Cialis were filled in the US, generating a combined $3 billion in sales, according to health data and clinical resea AutoNews- Source: http://www.dailymail.co.uk/health/article-5152483/Viagra-goes-generic-Pfizer-launch-little-white-pill.html?ITO=1490&ns_mchannel=rss&ns_campaign=1490
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Shortness of breath? Learn more and get a better lung disease treatment plan with top experts. Visit our Online Expert Centers at https://diagnosticdetectives.com/expert-centers/ Exclusive interview / Dr. Anton Titov MD and Professor Dr. Aaron Waxman MD, leading pulmonary arterial hypertension, right heart failure and lung disease expert. Find out exact cause if you have shortness of breath - get a precise diagnosis and best treatment for shortness of breath root cause. - Pulmonary arterial hypertension treatment. You mentioned phosphodiesterase type 5 inhibitors. They are also used for erectile disfunction. Common medications are viagra, sildenafil, and there are other medications of that class. So they're also used to treat pulmonary arterial hypertension. What is a typical way how they are used for pulmonary arterial hypertension? Are they effective? There is probably a different dosing schedule of those medications? So phosphodiesterase 5 inhibitors are in the nitric oxide pathway. And nitric oxide response, which really is our most potent vasodilator, works through cyclic GMP. So all the phosphodiesterase 5 inhibitors do is keep that cyclic GMP around longer by preventing its breakdown. And within the same path now we also have a medication called Riociguat, which is a soluble guanylate cyclase stimulator. So it actually increases the amount of available cyclic GMP and works in parallel with nitric oxide or independently of nitric oxide in pulmonary arterial hypertension. These patients generally have inadequate NO production. So all of these drugs are vasodilators. There's probably some added benefit, although we don't fully understand yet how, as far as remodeling - both myocardial remodeling and vascular remodeling. But there's no way to know which patients are going to get the most benefit from each individual drug. But I would say from an efficacy standpoint they're all pretty equivalent in pulmonary arterial hypertension. We don't combine them, but as individual drugs they're all pretty equivalent. - Are they used early in a therapy of pulmonary arterial hypertension, or when the first line therapy fails? - No, they probably are now first line therapy. Certainly sildenafil and tadalafil are considered first-line therapy, because they're generally very well tolerated and they're easy to use and they've been around for a long time in pulmonary arterial hypertension. I think Riociguatis a little more complicated to use because there's titration involved and it has a little more broader FDA approval targeting. It includes chronic thromboembolic disease but otherwise it's probably equally effective in pulmonary arterial hypertension. - Is the typical dosage [of PDE5 inhibitors in PAH] continuous or daily? Is it a smaller dose to compare with doses used for erectile disfunction indications? - When we did the clinical trials in pulmonary arterial hypertension, we studied sildenafil at 20 milligrams, 40 milligrams and 80 milligrams, at 3 times per day. So the usual dose for erectile dysfunction is 25, 50 and 75 mg, and a 100 mg, "when you need it". So certainly during the clinical trial, before the drug was approved, we were using Viagra at those doses. So I think there's room for dose adjustment. The only dose that was approved was 20 milligrams three times a day. So from an insurance standpoint we might have a little difficulty changing dose. But we often do titrate the dose, and Tadalafilwe use it at 40 milligrams once a day. - Every day? So with this frequent and fairly large dosing for pulmonary arterial hypertension treatment, as far as the cardiovascular side effects or other side effects, have you seen any major side effects? It's interesting, because the reason we went to these drugs are because phosphodiesterase 5 is predominantly localized to the vessels of the lung and the vessels of the penis. So we actually don't see a huge incidence of cardiovascular side effects. There are some patients whose blood pressure may be a little soft [low] with these drugs. But most patients with pulmonary arterial hypertension tolerate it quite well. I think the most important side effect that we see is headache, and it's not a bad headache. But it can be a nuisance. But it's usually readily responsive to simple things like Tylenol and aspirin or a non-steroidal anti-inflammatory medications.
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